Perioperative Haemostasis, Procedure-Related Pain After Physiological or Pharmacological Modifications of Local Anaesthesia Around the Eyes

ConditionsDermatochalasis of Upper Eyelid Blepharoplasty

Trial statusNot yet recruiting

Trial phasePhase 3

Trial typeInterventional

Biological sexAll

Age18+

SponsorPrince of Wales Hospital, Shatin, Hong Kong

About this trial

The goal of this clinical trial is to determine whether buffering, warming, or addition of hyaluronidase or tranexamic acid to lignocaine during eyelid injection of local anaesthesia reduce injection pain and procedure-related pain and improve perioperative haemostasis.

Eligibility criteria

Qualifiers

Patients undergoing bilateral upper eyelid blepharoplasty requiring subcutaneous anaesthesia at Prince of Wales Hospital, Alice Ho Miu Ling Nethersole Hospital and CUHK Medical Centre; and

Adult patients aged 18 or above.

Disqualifiers

Patients aged less than 18;

Pregnancy;

Allergy to local anaesthetic agents;

History of previous eyelid surgery; and

Trial design

Treatments tested in this trial

Sodium Bicarbonate (NaHCO3)
Warmed lignocaine
Hyaluronidase Injection
Tranexamic Acid (TXA)
Lignocaine 2% concentration solution

Treatment groups

80 Participants

are divided into 7 treatment groups

Treatment groups

See each treatment group below.

Sponsors and collaborators

Prince of Wales Hospital, Shatin, Hong Kong

Lead sponsor

Chinese University of Hong Kong

Collaborator

Source ClinicalTrials.gov