About this trial
Vitamin D plays a significant part calcium and phosphate haemostasis, thus, intrinsically critical for bone health. Increasing evidence also reveal that insufficient serum vitamin D levels also result in poor muscle health with such individuals having a compromised muscle building potential (4 times slower muscle building).
Muscle health is a critical component of a post-surgical patient recovery, with impaired muscle function leading to reduced functional ability, resulting in a poorer quality of life. Poor muscle health also has negative repercussion on survivability, with reduced overall, and disease-specific survival, especially shown in cancer patients. Thus, maintenance of vitamin D levels post-surgery may be more critical than previously thought.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Serum 25-hydroxyvitamin D levels between 30-50ng/ml at 4-6 weeks after operation
aged 21-65 years
ability to provide informed consent
accepts to take vitamin D supplements post-operatively and
Disqualifiers
They have undergone minor procedures (Table code <4a)
have a history of chronic kidney disease/end staged renal failure
have previous history of ureteric/kidney stones
known hyperparathyroidism
Trial design
Parallel
Treatments tested in this trial
Vitamin D
DrugHigh dose oral vitamin D supplementation (50,000 IU/once per month)
Treatment groups
Trial outcomes
Primary outcomes
serum 25-hydroxyvitamin D levels at 3-months post-intervention
serum 25-hydroxyvitamin D levels at 3-months post-intervention
Secondary outcomes
serum 25-hydroxyvitamin D levels compared to SOC at 6-months post-intervention.
serum 25-hydroxyvitamin D levels compared to SOC at 6-months post-intervention.
serum 25-hydroxyvitamin D levels compared to SOC at 12-months post-intervention.
serum 25-hydroxyvitamin D levels compared to SOC at 12-months post-intervention.
functional outcome measures at 3-months post-intervention
functional outcome measures at 3-months post-intervention
functional outcome measures at 6-months post-intervention
functional outcome measures at 6-months post-intervention
Sponsors and contacts
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Sengkang General Hospital
Lead sponsor
Hyphens Pharma Pte Ltd
Collaborator