Study of ALK-001 on the Progression of Stargardt Disease
ConditionStargardt Disease
Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age8-45
SponsorAlkeus Pharmaceuticals, Inc.
About this trial
This study evaluates the efficacy and safety of investigational study drug ALK-001 in participants 8 to 45 years of age, inclusive, with symptoms and signs of autosomal recessive Stargardt disease (STGD)
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Male or female, 8 to 45 years of age (inclusive) on the day of screening.
Female participants of childbearing potential, as well as fertile male participants with female partners of childbearing potential, must be willing to comply with the protocol-defined methods of contraception from the time of consent until 90 days and 30 days, respectively, after the last dose of IMP.
Have a clinical diagnosis of typical autosomal recessive STGD macular dystrophy
Have provided a genetic report by any regional accredited organization that provides certified testing indicating the presence of disease-causing mutation.
Disqualifiers
Has taken disallowed items (supplements containing vitamin A or beta-carotene, liver-based products, or prescription oral retinoid medications) within 30 days of randomization.
Is lactating, pregnant, or has a positive serum or urine pregnancy test at screening or at randomization, or is planning to become pregnant during the course of study. A male participant who wishes to father a child during the course of the study.
Has ever participated in any gene therapy, cell therapy, or device study to treat STGD, unless documented confirmation of participation in the placebo arm with no surgery is provided. Has participated in a drug study to treat STGD within the past 6 months.
Has participated in any drug study to treat any other condition within 5 half-lives of the investigational drug prior to screening, unless documented confirmation of participation in the placebo arm is provided. Has participated in an investigational device study within 30 days prior to screening or longer if, in the Investigator's judgment, the device could affect study outcomes.
Trial design
Design model
Parallel
Treatments tested in this trial
ALK-001
DrugDaily oral administration for 24 months
Placebo
DrugDaily oral administration for 24 months
Treatment groups
230 Participants
are divided into 2 treatment groupsGroup A: ActiveActive comparator 1 intervention
Group B: PlaceboPlacebo comparator 1 intervention
Trial outcomes
Primary outcomes
1
Annualized growth rate of retinal atrophic lesions measured by Fundus Autofluorescence
Annualized growth rate of retinal atrophic lesions measured by Fundus Autofluorescence
Time frame
Month 6 to Month 24Secondary outcomes
1
Changes in Low Luminance Visual Acuity from baseline to Month 24
Changes in Low Luminance Visual Acuity from baseline to Month 24
Time frame
baseline to Month 24Sponsors and contacts
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Source ClinicalTrials.gov