Use of Iv Tramadol and Ketamine for Prevention of Post Spinal Anesthesia Shivering

Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexFemale
Age18-40
SponsorLiaquat National Hospital & Medical College

About this trial

\*Ketamine:\* Ketamine is a medication that can help reduce shivering by blocking certain nerve signals in the brain. It's like a "nerve blocker" that helps calm down the body's shivering response.

\- \*Tramadol:\* Tramadol is a pain medication that can also help reduce shivering. It works by affecting the brain's temperature regulation centers, which helps to reduce the shivering response.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Pateint for elective cesarean section

Age 18 to 40 years

ASA 1 and 2

Disqualifiers

ASA 2 and 3

Cesarean section requiring general anesthesia

Hypersensitivity to Ketamine, Tramadol and Opiods

History of cardiovascular disease

Trial design

Design model

Parallel

Treatments tested in this trial

  • Ketamine only

    Drug

    Inj: Ketamine given to group K following spinal anesthesia

  • Tramadol

    Drug

    Inj Tramadol given to group T following spinal anesthesia

Treatment groups

250 Participants
are divided into 2 treatment groups
Group A: Group KActive comparator 1 intervention
Group B: Group TActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Shivering

Scale validated by crossley and mahajan Grade 0: No shivering Grade 1: Piloerection, peripheral vasoconstriction, peripheral cyanosis, or mild fasciculation of the face or neck, but no visible muscle activity Grade 2: Visible muscle activity in one muscle group Grade 3: Visible muscle activity in more than one muscle group Grade 4: Gross muscle activity involving the entire body

Time frame
20 minutes to 12 hours

Secondary outcomes

Other outcomes

Sponsors and contacts

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