XePOHCAS: Prospective, randomized, multicenter interventional trial in adult subjects with out-of-hospital cardiac arrest comparing treatment with standard-of-care post-cardiac arrest intensive care (which is targeted temperature management \[TTM\]) to xenon by inhalation plus standard-of-care post-cardiac arrest intensive care (including TTM).
Age at least 18 years but less than or equal to 80 years
Presumed cardiac cause of arrest
Sustained (>20 minutes) spontaneous circulation upon arrival in the emergency department
No response to verbal commands on arrival to emergency department and prior to randomization (Glasgow Coma Scale score of <8)
Written do not attempt resuscitation reported to providers before randomization
Traumatic etiology of arrest, defined as concomitant blunt, penetrating, or burn-related injury, or uncontrolled bleeding or exsanguination
Suspected or known stroke or intracranial hemorrhage
Unwitnessed cardiac arrest
Parallel
Xenon
Combination product50% xenon by inhalation, delivered by customized xenon delivery system, that includes a ventilator, for the 24h period of TH/TTM. The inhalation therapy is provided in combination with protocol-directed Post-Cardiac Arrest Care dictated by the 2015 guidelines from the American Heart Association and the European Resuscitation Council.
functional outcome: degree of functional independence measured using a modified Rankin Scale (mRS)
The degree of functional independence will be measured using a modified Rankin Scale (mRS)
survival: number of survivors
The number of survivors will be measured
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