Acetaminophen vs Placebo for Postoperative Analgesia After Abdominal Surgery

Trial statusNot yet recruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorKonya City Hospital

About this trial

This study investigates whether oral acetaminophen, when added to standard pain management, reduces opioid use and pain after major abdominal surgery, compared to a placebo (inactive pill). Patients undergoing planned abdominal surgery under general anesthesia will be randomly assigned to receive either acetaminophen or a placebo tablet before surgery and every 6 hours afterward for 48 hours, in addition to their usual pain medication. Researchers will measure how much opioid pain medication patients need, how much pain they report, and how satisfied they are with their pain control during the first two days after surgery. The goal is to determine whether oral acetaminophen provides a genuine benefit beyond placebo in reducing opioid use while maintaining adequate pain control.

Eligibility criteria

Qualifiers

Written informed consent

Age ≥ 18 years

ASA physical status I, II, or III

Scheduled for elective non-cardiac abdominal surgery with expected surgery duration ≥ 2 h-hours

Disqualifiers

Pregnant or nursing (breastfeeding) women

Neurologic deficit or chronic pain disease

Planned use of regional anesthesia techniques for postoperative pain

Emergency surgery

Trial design

Treatments tested in this trial

  • Acetaminophen

Treatment groups

1,504 Participants
are divided into 2 treatment groups

Locations

This trial has no locations

Sponsors and collaborators

Konya City Hospital

Lead sponsor

Erzurum Regional Training & Research Hospital

Collaborator