Aging, Beta Blockers, and Thermoregulatory Responses
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age65+
SponsorUniversity of Texas Southwestern Medical Center
About this trial
This study will test the hypothesis that the drugs propranolol and metoprolol will result in greater increases in core body temperature during 3 hours of extreme heat exposure in older adults.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Healthy and free of any significant medical problems
Normal resting electrocardiogram
65+ years of age
Controlled cholesterol of less than 200 mg/dl
Disqualifiers
Known diseases or other chronic conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, uncontrolled hypertension, and uncontrolled hypercholesterolemia
Serious abnormalities detected on routine screening
Taking prescribed medications or over-the-counter medications that have known influences on either cardiac function or sweating
Current smokers, as well as individuals who regularly smoked within the past 3 years
Trial design
Design model
Crossover
Treatments tested in this trial
Ambient Heat
Other interventionSubjects will spend 3-hours in a heat chamber at 41°C and 40% humidity.
Treatment groups
22 Participants
are divided into 6 treatment groups6
Treatment groupsSee each treatment group below.
Group A: Placebo, then Propranolol, then MetoprololExperimental treatment 1 intervention
Group B: Placebo, then Metoprolol, then PropranololExperimental treatment 1 intervention
Group C: Propranolol, then Placebo, then MetoprololExperimental treatment 1 intervention
Group D: Propranolol, then Metoprolol, then PlaceboExperimental treatment 1 intervention
Group E: Metoprolol, then Placebo, then PropranololExperimental treatment 1 intervention
Group F: Metoprolol, then Propranolol, then PlaceboExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Internal temperature
The change in internal temperature to the 3-hour heat exposure will be measured.
Time frame
Continuously throughout the 3-hour heat exposure.2
Whole body sweat rate
Whole body sweat rate will be measured via changes in pre/post nude body mass.
Time frame
Nude body mass will be measured before and after the 3-hour heat exposure.Secondary outcomes
1
Heart rate
Heart rate will be measured via electrocardiogram.
Time frame
Continuously throughout the 3-hour heat exposure.2
Arterial blood pressure
Systolic and diastolic arterial blood pressures will be measured via a brachial blood pressure cuff.
Time frame
Continuously throughout the 3-hour heat exposure.Sponsors and contacts
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Source ClinicalTrials.gov