Alpha-Blockers Prior to Ureteral Access Sheath Placement in Flexible Ureteroscopy: A Randomized Prospective Study

Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorPedro de Figueiredo Buchalla

About this trial

This study aims to evaluate whether the use of alpha-blockers before flexible ureterorenolithotripsy facilitates the passage of the ureteral access sheath. The trial will enroll adult patients diagnosed with kidney stones who are scheduled for flexible ureteroscopy. Participants will be randomly assigned to receive or not receive alpha-blockers for seven days before surgery. The primary outcome is the rate of successful sheath placement without the need for a second procedure. Secondary outcomes include the incidence of ureteral injuries and the need for additional surgical interventions. The goal is to improve surgical efficiency and patient outcomes in the treatment of kidney stones.

Eligibility criteria

Qualifiers

Age ≥ 18 years

Diagnosis of nephrolithiasis with surgical indication for flexible ureterorenolithotripsy

Ability to provide written informed consent

Disqualifiers

Age < 18 years

Pregnancy

History of ureteral stricture, prior ureteral reconstructive surgery, and/or abdominal or pelvic radiotherapy

Prior ureteroscopy or ipsilateral double-J stent placement within the past 3 months

Trial design

Treatments tested in this trial

  • Experimental: Alpha-blocker group
  • No intervention (observational study)

Treatment groups

140 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Pedro de Figueiredo Buchalla

Lead sponsor

Centro Universitário FMABC

Sponsor institution