Anesthetic Effectiveness of Lidocaine Versus Articaine in Dentistry

ConditionDental Pain
Trial statusNot yet recruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18-65
SponsorUniversidad Austral de Chile

About this trial

Context: Lidocaine and articaine are two of the most commonly used local anesthetics in dentistry. Lidocaine has often been the anesthetic of choice in clinical practice, but in clinical experience, articaine has proven to be more effective in controlling pain during dental procedures. (Camps-Font, O. et al. 2020).

There are still unanswered questions, such as which of the two local anesthetics is more effective in reducing pain? This could lead us to discuss which one to choose to reduce costs in the dental office.

Objective: The objective of this project is to determine and compare the effectiveness of lidocaine and articaine in clinical contexts such as tooth extraction with infiltrative techniques, seeking to provide answers that will optimize the choice of anesthetic based on the patient and the procedure, thus improving pain management and reducing costs in the dental office.

Design: Randomized double-blind experimental study, parallel groups. The control group received 2% lidocaine, and the experimental group received 4% articaine. The study will be conducted in accordance with the guidelines of the Consolidated Standards of Reporting Trials (CONSORT 2010). The probabilistic sampling technique is through simple randomization. The 100 patients who meet the inclusion criteria will be randomly assigned to the control and experimental groups in a 1:1 ratio.

Expected results: articaine shows a lower percentage of extractions with anesthetic reinforcement and, therefore, a lower average number of additional tubes.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Patients with clinical indications for simple extraction of upper and lower teeth using infiltrative anesthetic techniques.

Patients without systemic diseases (ASA I)

Patients with controlled systemic disease (ASA II)

Patients with no history of hypersensitivity to anesthetics or their components (epinephrine)

Disqualifiers

Patients with uncontrolled systemic diseases ASA III and pregnant patients.

Patients requiring trunk techniques (Gow gates, Spix, Carrea)

Patients taking medication that affects the anesthetic response (tricyclic antidepressants, anticoagulants)

Patients with a history of neurological or psychiatric disorders that may influence the perception of pain or anxiety.

Trial design

Design model

Parallel

Treatments tested in this trial

  • lidocaine + epinephrine 1:100,000

    Drug

    Administration of lidocaine as a local anesthetic during dental extraction.

  • Articaine 4% with epinephrine 1:100,000

    Drug

    Administration of articaine as a local anesthetic during dental extraction.

Treatment groups

100 Participants
are divided into 2 treatment groups
Group A: LidocaineActive comparator 1 intervention
Group B: ArticaineExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Number of tubes

continuous quantitative variable

Time frame
immediately after the procedure

Secondary outcomes

1

Pain during dislocation using the Visual Analog Scale (VAS) for pain with a minimum of 0 meaning no pain, and a maximum of 10 meaning the most severe pain ever experienced in life.

Continuous quantitative variable

Time frame
After the procedure

Other outcomes

1

Age

Continuous quantitative variable.

Time frame
immediately after the procedure
2

Sex

Nominal qualitative variable.

Time frame
Immediately after the procedure.

Sponsors and contacts

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This trial is not recruiting at the moment. You can still explore other options: