The primary objective of this study is to evaluate the biochemical efficacy of Magnesium Sulfate (MgSO₄) as an anti-inflammatory therapeutic agent in patients suffering from moderate traumatic brain injury (TBI) at Assiut University Hospitals by measuring Nucleotide-binding oligomerization domain-Like Receptor Pyrin domain-containing 3 (NLRP3) inflammasome-a multiprotein complex.
Male and female patients aged 18 to 60 years.
Sustained a closed head trauma with the study drug infusion initiated within 8 hours of the injury.
TBI confirmed by history and clinical examination.
Patients with moderate (GCS = 9-12) traumatic brain injury.
Patient Refusal
Prolonged and/or uncorrectable hypoxia (PaO₂ < 60 mmHg) or persistent hypotension (systolic blood pressure < 90 mmHg) at the time of randomization.
Cardiopulmonary arrest.
Concomitant spinal cord injury.