Antibacterial Effect of Two Different Intracanal Medicaments and Their Effect on Post-operative Pain

ConditionPulp Necrosis
Trial statusNot yet recruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18-50
SponsorAin Shams University

About this trial

Evaluation of antibacterial effect of two different intracanal medicaments on bacterial load in infected mature permanent teeth and their effect on post-operative pain level.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

free medical history,

mature infected permanent single rooted teeth diagnosed clinically and radiographically with adequate coronal structure for proper isolation, temporization and restoration.

Disqualifiers

Patients who are not included in the age range of the study or having a systemic condition.

Teeth with severe fractures or resorption or periodontally compromised.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Calcium Hydroxide (Ca(OH)2)

    Drug

    Non setting calcium hydroxide intracanal medicament is injected through the root canal for two weeks

  • chitosan nanoparticles gel

    Drug

    Nano chitosan gel is injected through the root canal as an intracanal medicament for two weeks

Treatment groups

52 Participants
are divided into 3 treatment groups
Group A: calcium hydroxide (Ca(OH)2)Active comparator 1 intervention
Group B: Chitosan nano particles (CNPs)Experimental treatment 1 intervention
Group C: controlNo intervention 0 interventions

Trial outcomes

Primary outcomes

1

Bacterial load.

Samples will be collected from the infected root canal before and after injection of intracanal medicaments then bacterial colonies will be counted for colony forming units per milliliter (CFU/ml) to assess the effect of the intracanal medicaments used.

Time frame
two weeks

Secondary outcomes

1

Visual Analogue Scale (VAS) to measure post operative pain level.

the patient is given a 10 cm sheet to mark their pain level where (0) represents no pain and (10) the worst pain.

Time frame
12 hours, 24 hours, 48 hours, 72 hours.

Other outcomes

Sponsors and contacts

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