Health TrialsbyHealthPanel

Blood Pressure Control With Thiazide Diuretics in Peritoneal Dialysis Patients

ConditionsHypertensionPeritoneal DialysisEnd Stage Kidney Disease (ESRD)
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorChinese University of Hong Kong

About this trial

To evaluate the blood pressure lowering effects of thiazide diuretics in patients on peritoneal dialysis

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients on chronic peritoneal dialysis, with uncontrolled hypertension (SBP >140 mmHg and/or DBP >90 mmHg)

Disqualifiers

Patients with a life expectancy of less than 3 months, planned conversion to hemodialysis, or scheduled kidney transplantation within 3 months

Trial design

Design model

Crossover

Treatments tested in this trial

  • Hydrochlorothiazide 25mg once per day

    Drug

    Thiazides diuretics

Treatment groups

40 Participants
are divided into 2 treatment groups
Group A: Thiazides treatment armActive comparator 1 intervention
Group B: Control armNo intervention 0 interventions

Trial outcomes

Primary outcomes

1

Change in systolic and diastolic blood pressure

Time frame
90 days

Secondary outcomes

1

Changes in body weight

Time frame
90 days
2

Changes in body composition measured by bio impedance spectroscopy

Time frame
90 days
3

Change in urinary fractional excretion of sodium

Time frame
90 days

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Chinese University of Hong Kong

Lead sponsor

Source ClinicalTrials.gov
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