Buprenorphine, Clonidine, and Dexamethasone on Duration of Brachial Plexus Blocks for Upper Extremity Surgery

Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorLoyola University

About this trial

The goal of this clinical trial is to learn if there is a difference in morphine requirements in patients after upper extremity surgeries including shoulder arthroscopy. The main question it aims to answer is whether there is a difference between Interscalene brachial plexus blocks with the addition of buprenorphine, dexamethasone, and clonidine and the same block without the adjuvant.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients ≥ 18 years old

Patients undergoing shoulder arthroscopy

Patients willing to participate and sign informed consent

Disqualifiers

Severe COPD/other contraindication to general anesthesia

Patient with a weight of less than 60 kg

Dementia, not alert or oriented to person, place, or time

Chronic pain patient with daily opioid use at home.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Interscalene block with the addition of buprenorphine, clonidine, dexamethasone

    Drug

    Addition of the adjuvant buprenorphine, dexamethasone, and clonidine in the nerve block performed prior to shoulder arthroscopy surgery

  • Interscalene block with buprenorphine alone

    Drug

    Addition of the adjuvant buprenorphine alone the in nerve block performed prior to shoulder arthroscopy surgery

Treatment groups

120 Participants
are divided into 2 treatment groups
Group A: Interscalene block with the addition of buprenorphine, clonidine, dexamethasoneExperimental treatment 1 intervention
Group B: Interscalene block with buprenorphine aloneActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Morphine requirement post surgery

To compare the morphine equivalents administered in the first 24 hours after arrival in the recovery area between the two groups.

Time frame
24 hours

Secondary outcomes

1

Pain reported via a numeric rating scale (NRS)

To measure pain via a numeric rating scale (NRS) immediately after arrival to recovery area from surgery (time: 0hr), and again at 2, 24, and 48 hours.

Time frame
48 hours

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.