Over 80% of patients who undergo surgery suffer from acute postoperative pain, with 75% of them rating the pain severity as moderate, severe, or extreme. Studies have shown that less than 50% of patients who undergo surgery report adequate relief from postoperative pain.
Additionally, if pain is not promptly managed after surgery, it can hinder a patient's ability to walk, potentially causing adverse effects such as thromboembolism, myocardial ischemia, and arrhythmia.
The opioid analgesics are most commonly used as parenteral agents to manage post operative pain but the problem of respiratory depression remains to be considered.
This study is designed to compare the analgesic effect between dexmedetomidine versus magnesium sulfate as adjuvant to bupivacaine using ultrasound guided Transversus Abdominis Plane block in patients undergoing abdominal hysterectomy
ASA classification I-ll,
Aged >18 years,
weight 50-85 kg,
Patients who will undergo total abdominal hysterectomy
• ASA classification I-ll,
Aged >18 years,
weight 50-85 kg,
Patients who will undergo total abdominal hysterectomy
Parallel
bupivacaine 0.5%
Drugpatients will receive 18 ml 0.5% bupivacaine (Sunnypivacaine®) using Ultrasound-Guided TAP Block Technique
Dexmedetomidine
Drugpatients will receive plus 0.5 µg/kg of dexmedetomidine (Precedex® 100 µg/ml) diluted in 2 ml of normal saline at each side
MgSO4
Drugpatients will receive plus 1.5 mL (150 mg) MgSO4 and 0.5 mL normal saline at each side
the time of the first request of rescue analgesia
the time of the first request of rescue analgesia (calculated from the time of the TAP block application)
Click on the lead sponsor to view all of their trials.
This trial is not recruiting at the moment. You can still explore other options:
