The primary aim of this clinical trial is to compare the effectiveness of fentanyl vs morphine as analgosedation in mechanically ventilated adult patients in the ICU. This study also aims to compare the outcomes of patients between the two groups.
The main questions it aims to answer are :
1. Does propofol and fentanyl infusion as analgo-sedation achieve targeted sedation score at 12 and 24 hours compared to propofol and morphine infusion in mechanically ventilated adult patients in the intensive care unit (ICU)? 2. Is there a difference between the proportion of patients requiring rescue sedation dose between the fentanyl and morphine groups?
Age >18 years old
Patients who are expected by the ICU team to require invasive mechanical ventilation in ICU for at least more than 24 hours and for whom the ICU team decides to initiate continuous infusion of sedation
A patient who was ventilated and sedated not more than 12 hours before ICU admission.
Patients with chronic use of narcotics
Patients with chronic liver failure or end-stage renal failure
Patients with severe chronic neurocognitive dysfunction
Patients with drug overdose
Parallel
Fentanyl
DrugIntravenous fentanyl infusion with dilution of 10mcg/ml
Morphine
DrugIntravenous morphine infusion with dilution 1mg/ml
RASS score at 12 and 24 hours
To determine the proportion of patients achieving the targeted sedation guided by RASS score at 12 and 24 hours in both fentanyl and morphine group.
Rescue sedation doses
To determine the proportion of patients requiring rescue sedation doses between fentanyl and morphine group
Duration of mechanical ventilation
To compare the duration of mechanical ventilation between the fentanyl and morphine groups
Length of ICU stay
To compare the length of ICU stay between the fentanyl and morphine groups
14 days mortality rate
To compare 14-day mortality rates between the fentanyl and morphine groups
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