Comparing Spinal Anesthesia With 1% Chloroprocaine Versus 1% Mepivacaine in Patients Undergoing Outpatient Primary Total Knee Arthroplasty

ConditionsRecovery Period Anesthesia

Trial statusNot yet recruiting

Trial phasePhase 4

Trial typeInterventional

Biological sexAll

Age18+

SponsorNova Scotia Health Authority

About this trial

This study or clinical trial looking to compare 2 types of freezing medications injected into the spinal fluid at the lower back between the vertebrae in patients going to have total knee replacement surgery to check for early legs movement, early discharge from recovery room, walking and hospital discharge. This could save hospital cost of such procedures.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

ASA I-III

Elective outpatient TKA

BMI less than 40

Ability to provide surgical consent

Disqualifiers

Patient refusal

Opioid tolerant

Any contraindications to spinal anesthesia

Chronic opioid use 3months or more

Trial design

Design model

Parallel

Treatments tested in this trial

Mepivacaine Injection
Drug
Comparing time to motor block recovery in PACU, time to PACU discharge, time to ambulation and length of hospital stay
Chloroprocaine Injection
Drug
Comparing time to motor block recovery in PACU, time to PACU discharge, time to ambulation and length of hospital stay

Treatment groups

170 Participants

are divided into 2 treatment groups

Group A: One arm receives spinal Mepivacaine 50 mgActive comparator 1 intervention

Group B: Spinal Chloroprocaine groupActive comparator 1 intervention

Trial outcomes

Primary outcomes

Time to complete recovery of motor block

Time frame

Time from the intrathecal drug injection to the first documented instance of complete motor block recovery Bromage 0. Within approximately 2 hours for the Chloroprocaine group and 4 hours for the Mepivacaine group.

Time to complete motor block recovery of lower limbs after spinal anesthesia

Motor block will be assessed by PACU nurses in PACU using standard Bromage motor scale.

Time frame

From the time of intrathecal drug injection to PACU discharge. Within approximately 3 hours for the Chloroprocaine group and 5 hours for the Mepivacaine group.

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Nova Scotia Health Authority

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: