This study will focus on grade I to III knee osteoarthritis by randomized controlled trials which comparing the effectiveness between placebo, autologous platelet rich plasma and autologous platelet lysate injections.
50 to 80 years old
Study Subjects must be willing to sign Informed Consent to participate in the study
In the past month, at least seven consecutive days in the squat, standing, walking or going up and down the stairs, the most serious degree of visual analogy of the knee pain (Visual Analogue Scale) is greater than or equal to 40 (the most pain is 100, not painful is 0)
Morning joint stiffness is less than 30 minutes
Knee instability
The knee joint is obviously deformed (> 5 degree valgus or varus deviation on X-ray)
Clinical diagnosed as Pes tendinitis, Chondromalacia
Taking NSAIDs or steroids (including oral and injection) within one week
Parallel
Saline injection
Other intervention5ml Placebo infusion of 0.9% Sodium Chloride
PRP injection
Biological/VaccineDevice: "Aeon" Acti-PRP 5ml autologous platelet rich plasma injection
PL injection
Biological/VaccineDevice: "Aeon" Acti-PRP 5ml autologous platelet lysate injection
Pain score of the patient
Using Visual Analog Score (from 0 to 10, 0 indicate no pain and 10 indicate maximal pain) to evaluate pain of surgical wound of the patient
Knee functional score
Using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)
X-ray
Knee X-ray image
Ultrasonic image
Ultrasonic-between thickness of the medial and lateral sides of the femoral condyle
adverse events
adverse events in clinical trial
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