Comparison of Intralesional Triamcinolone Versus Verapamil for Keloid Treatment

ConditionKeloid Scars

Trial statusNot yet recruiting

Trial phasePhase 4

Trial typeInterventional

Biological sexAll

Age10-50

SponsorNishtar Medical University

About this trial

This study aims to compare the efficacy of intralesional triamcinolone and verapamil in patients presenting with keloid at our local setting. The results will guide us towards better management of keloids by choosing the more appropriate treatment. Adequate treatment will reduce significant emotional and physical distress in patients. We hypothesized that mean reduction in Vancouver Scar Score is higher in triamcinolone acetonide group compared to verapamil after three months of treatment.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

size of keloid1-5 cm,

on any site of the body,

duration less then five years and

baseline Vancouver scar score of more the or equal to 5

Disqualifiers

Pregnant or lactating women,

family history of keloids,

acromegaly, and

congestive cardiac diseases

Trial design

Design model

Parallel

Treatments tested in this trial

Triamcinolone Acetonide 1 ml of 40 mg/mL suspension
Drug
Monthly intralesional injection
Verapamil Injection
Drug
2.5 mg of intralesional Verapamil injection monthly

Treatment groups

60 Participants

are divided into 2 treatment groups

Group A: Verapamil TreatmentActive comparator 1 intervention

Group B: Triamcinolone TreatmentExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

Change in Vancouver Scar Score

The Vancouver Scar scale assesses four parameters of vascularity, pigmentation, pliability and height. The total score ranges from 0 - 13.

Time frame

Vancouver Scar score will be measured at baseline (before treatment assignment) and then 4-weeks after completion of treatment - 16-weeks after randomization.

Sponsors and contacts

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Nishtar Medical University

Lead sponsor

Source ClinicalTrials.gov

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