Continuous Infusion Versus Intermittent IV Bolus of Cefazolin: Prevention of Surgical Site Infection During CABG Surgeries in Egyptian Patients.

ConditionSurgical Site Infection (SSI)

Trial statusNot yet recruiting

Trial phasePhase 4

Trial typeInterventional

Biological sexAll

Age18+

SponsorHelwan University

About this trial

A randomized controlled trial on adults who underwent coronary artery bypass grafting (CABG) surgery. To evaluate the effectiveness of intraoperative continuous infusion (CI) of cefazolin compared with intermittent (INT) cefazolin administration in preventing surgical site infection in the CABG population.

Eligible patients will be randomized using a block design into 2 groups: intervention and control. The intervention group will use continuous infusion of cefazolin (CI), while the control group will follow the traditional presurgical prophylaxis protocol of intermittent cefazolin doses (INT).

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Cardiothoracic ICU-admitted patients who underwent CABG on CPB.

Disqualifiers

Patients who require reoperation within 30 days.

Immunosuppressant patients.

Patients who are not adherent to the protocol time or dosing, either preoperatively, during, or postoperatively.

Pregnancy or breastfeeding.

Trial design

Design model

Parallel

Treatments tested in this trial

Cefazolin 2 g Infusion
Drug
To evaluate the effectiveness of intraoperative continuous infusion (CI) of cefazolin compared with intermittent (INT) cefazolin administration in preventing SSIs in a CABG (coronary artery bypass grafting) population.
Cefazolin 2 GM Injection
Drug
To evaluate the effectiveness of intermittent (INT) cefazolin administration in preventing SSIs in a CABG (coronary artery bypass grafting) population.

Treatment groups

100 Participants

are divided into 2 treatment groups

Group A: Intraoperative continuous infusion (CI) of cefazolinExperimental treatment 1 intervention

Group B: Intermittent (INT) cefazolinActive comparator 1 intervention

Trial outcomes

Primary outcomes

Incidence of SSI

Time frame

Within 3 months after surgery

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Helwan University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: