Dexamethasone in Prolonging the Duration of Spinal Anesthesia Among Pregnant Patients

Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexFemale
Age16-40
SponsorRawalpindi Medical College

About this trial

Lower segment C section is one of the most commonly performed surgeries worldwide. It is performed in spinal anesthesia. During Spinal Anesthesia a local anesthetic drug is administered in a space surrounding spinal cord and it blocks nerves originating from spinal cord providing both anesthesia and analgesia. This technique avoids harmful exposure of drugs to the baby inside the womb of mother. However this technique provides anesthesia and analgesia of limited duration which can be prolonged by addition of drugs to patient management regimen. One such drug is Dexamethasone which is a steroid commonly administered in the peri-operative period.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

American Society of Anesthesiologists (ASA) class: II and above.

Elective Cesarean section under Spinal Anesthesia.

Disqualifiers

Gestational diabetes

Body mass index >35 kg/m2

Diabetes mellitus

Adrenal insufficiency

Trial design

Design model

Parallel

Treatments tested in this trial

  • Dexamethasone

    Drug

    Immediately after sub-arachnoid block 8mg of Dexamethasone will be administered intravenously

  • Placebo

    Drug

    2ml of Normal saline will be given intravenously immediately after administration of spinal anesthesia

Treatment groups

110 Participants
are divided into 2 treatment groups
Group A: Group DexamethasoneExperimental treatment 1 intervention
Group B: Group ControlPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

1

Time for block to regress by two dermatomes in post operative period

Time frame
This will be the time in minutes from end of C section in post operative period for the block to regress by two dermatomes

Secondary outcomes

1

Time to rescue analgesia

Time frame
This will be the time in minutes from the end of Cesarean section in the post operative period to first rescue analgesia.

Other outcomes

Sponsors and contacts

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