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Effect of Endurance Training-Induced Coenzyme Q10 (CoQ10) Supplementation on Myokine, Exerkine Secretion and Cognitive Functions in Long-Distance Runners

ConditionHealth Knowledge, Attitudes, Practice
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexMale
Age30-50
SponsorGdansk University of Physical Education and Sport

About this trial

The goal of this clinical trial is to learn if CoQ10 amplifies endurance training-induced myokine and exerkine secretion and if those changes influences cognition in long-distance runners.

Does 4-week high-dosage CoQ10 supplementation increase the secretion of myokine, exerkine sercetion? Does the above-mentioned intervention improve the cognitive function in long distance runners?

Participants will:

Take CoQ10 or a placebo every day for 4 weeks. Visit the laboratory once every 4 weeks for checkups and tests. Keep the participants' food and training diary.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

training experienced for minimum 2 years

running training at least 2 times per week

Personal Best on 10k (<50 minutes)

Disqualifiers

taking supplements which can interrupt primary outcomes (vitamin D, omega-3 fatty acids)

injured in last 6 months to avoid n number reduction

Trial design

Design model

Crossover

Treatments tested in this trial

  • CoQ10 supplementation

    Dietary supplement

    Long-distance runners will be supplemented with CoQ10 for 4 weeks in cross-over manner with 4 weeks of wash out period.

  • Placebo supplementation

    Dietary supplement

    Long-distance runners will be supplemented with placebo for 4 weeks in cross-over manner with 4 weeks of wash out period.

Treatment groups

24 Participants
are divided into 2 treatment groups
Group A: CoQ10-treated participantsExperimental treatment 1 intervention
Group B: Placebo-treated participantsPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

1

Change in cognitive funtions as a result of CoQ10 supplementation measured via cogntitive function test.

The investigators assume that supplementation with CoQ10 will change cognition (measured via cognitive function tests - Stroop Test, Trial Making Test A and Trial Making Test B) in long-distance runners. The results will be obtained as time (seconds) needed to complete tasks while testing.

Time frame
The investigators are going to check this hypothesis after 4 weeks of high-dose supplementation with CoQ10
2

Change in myokine and exerkine concentration in the blood plasma as a result of CoQ10 supplementation.

The investigators will assess the concentration of blood myokine and exerkine concentration (pg or ug/dl) of blood plasma using the colorimetric method.

Time frame
The investigators are going to check this hypothesis after 4 weeks of high-dose supplementation with CoQ10

Secondary outcomes

1

Change in aerobic capacity measured via direct test to volitional exhaustion on a motorized treadmill

The investigators assume that supplementation with CoQ10 will change the aerobic capacity (oxygen uptake in ml-1 x min-1 x kg-1) in long-distance runners. The determination of aerobic capacity will be done through progressive test to volitional exhaustion on a motorized treadmill and gas analyzer

Time frame
The investigators are going to check this hypothesis after 4 weeks of high-dose supplementation with CoQ10

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Gdansk University of Physical Education and Sport

Lead sponsor

Source ClinicalTrials.gov
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