Effect of Tadalafil on Endometrial Thickness and Frozen Embryo Transfer Outcomes
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexFemale
Age18-43
SponsorBeni-Suef University
About this trial
investigate the effect of different vasodilators as Tadalafil in women with unexplained infertility using IVF
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
has good quality day five frozen embryos.
Disqualifiers
hypotension (blood pressure less than 90/50) and
history of stroke or myocardial infarction
Trial design
Design model
Parallel
Treatments tested in this trial
Tadalafil 5mg
Drugphosphodiesterase type 5 (PDE-5) inhibitor
estradiol valerate 2 mg
Drugestradiol valerate 2 mg. in form of (Cycloprogynova® Bayer Shering Pharma) white pills starting dose is one pill T.I.D may be increased to two pills T.I.D according to endometrial thickness in day 9 measured by vaginal ultrasound.
Treatment groups
100 Participants
are divided into 2 treatment groupsGroup A: (control)Active comparator 1 intervention
Group B: tadalafil 5 mgExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
pregnancy
whom Beta-Human Chorionic Gonadotropin (β-hCG) was positive
Time frame
1 monthSponsors and contacts
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Source ClinicalTrials.gov