About this trial
In the 20th century, tobacco caused the death of 100 million people worldwide and it is estimated that it will be responsible for 1 billion deaths in the 21st century. Currently 8 million people die each year from smoking, 7 million are associated with active smoking, thus being the main risk factor for loss of disability-adjusted life years for men and the ninth most important risk factor for women. In previous studies it has been reported that approximately 21% (14%-30%) of subjects who have required hospitalization are active smokers, being higher in men than in women (28% vs 14%). The initiation of treatment for smoking cessation in this group of subjects has shown an effectiveness rate of up to 65% to maintain abstinence 6 to 12 months after discharge. The effectiveness has been analyzed in scenarios with only brief advice, in some others with the use of medications such as varenicline, bupropion and nicotine replacement therapy, however, the interventions have not been standardized for adequate analysis, which could contribute to the different results.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
None
Disqualifiers
Subjects who have had pharmacological treatment to stop smoking in the last month
Subjects with contraindications for medications.
Trial design
Parallel
Treatments tested in this trial
Bupropion
DrugBupropion will be added at doses of 150 mg to 300 mg per day in addition to nicotine replacement therapy, counseling and cognitive behavioral therapy
Nicotine replacement therapy (Nicotine patches)
DrugNicotine replacement therapy (Nicotine patches) plus counseling and cognitive behavioral therapy
Treatment groups
Trial outcomes
Primary outcomes
Abstinence at 12 months. Negative cotinine test and negative an exhaled carbon monoxide test
Abstinence will be corroborated with a cotinine test and an exhaled carbon monoxide test. Negative urine cotinine test and an exhaled carbon monoxide test less than 6 ppb.
Sponsors and contacts
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