Health TrialsbyHealthPanel

Erector Spinae Plane Block Catheters and Intrathecal Morphine for Hepatic Resection

ConditionsHepatic ResectionAcute PainAnesthesiaAnesthesia, Local
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of California, San Diego

About this trial

To determine whether the addition of erector spinae plane (ESP) catheters to existing multimodal analgesic regimen with intrathecal morphine provides superior postoperative analgesia in patients undergoing hepatic resection compared with patients not receiving ESP catheters.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

undergoing hepatic resection

Admitting service requests APS consult

>18 years old and able to provide consent

Disqualifiers

pregnancy

incarceration

inability to communicate with the investigators and hospital staff

severe hepatic disease

Trial design

Design model

Parallel

Treatments tested in this trial

  • 0.2% ropivacaine local anesthetic continuous erector spinae plane block

    Drug

    Treatment- continuous erector spinae block catheter followed by an infusion of ropivacaine 0.2% at 10ml automatic set bolus per 60 minute with 2ml/hr continuous infusion (12mls/hr total per catheter)

  • 0.2% ropivacaine local anesthetic superficially taped continuous erector spinae plane block

    Drug

    Placebo- Superficially placed (taped to the surface) erector spinae block catheter with a ropivacaine 0.2% infusion at 0.1ml /hr

  • Spinal Morphine

    Drug

    200-300 mcg of spinal morphine

Treatment groups

70 Participants
are divided into 2 treatment groups
Group A: Active TreatmentExperimental treatment 2 interventions
Group B: PlaceboPlacebo comparator 2 interventions

Trial outcomes

Primary outcomes

1

Total opioid requirement postoperative day (POD) 1-3

Morphine Milligram Equivalents

Time frame
Total use from post-operative day (POD) 1, as defined by 24 hours after intrathecal morphine, to POD 3 (3 days from admission to recovery unit)

Secondary outcomes

1

Total opioid requirement postoperative day (POD) 0-4

Morphine Milligram Equivalents

Time frame
Total use from hospital admission to POD 4 (4 days after admission to recovery unit)
2

Pain Score at rest and with cough

Average pain score on the 10-point numeric rating scale (0 being no pain, 10 worst pain)

Time frame
Post-Operative Day 0, 1, 2, 3, 4, 14, 30
3

Discharge opioids and refills.

Amount of opioids prescribed at discharge and amount taken/refills while at home

Time frame
Typically within 14days of admission, then at 14 days, and at 30 days.
4

Nausea

Defined by number of antiemetics administered

Time frame
Post-Operative Day 0, 1, 2, 3, 4

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of California, San Diego

Lead sponsor

Source ClinicalTrials.gov
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