Lidocaine, Paracetamol, and Dexmedetomidine for Rocuronium Injection Pain

ConditionsPropofol Injection Pain Rocuronium Injection Pain

Trial statusNot yet recruiting

Trial phasePhase 4

Trial typeInterventional

Biological sexAll

Age18-65

SponsorBaskent University

About this trial

Propofol and rocuronium may cause pain during intravenous injection. Various pharmacological agents are used to reduce the incidence and severity of injection pain. Among the most commonly used agents for this purpose are lidocaine, various opioids, ketamine, paracetamol, and dexmedetomidine. The aim of this study was to evaluate the comparative effect of intravenous dexmedetomidine and paracetamol versus lidocaine in preventing propofol- and rocuronium-induced pain during anesthesia induction.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

None

Disqualifiers

None

Trial design

Design model

Parallel

Treatments tested in this trial

Lidocaine %2 ampoule
Drug
Patients who were administered 40 mg lidocaine.
Dexmedetomidine
Drug
Patients who were administered 0.25 mg/kg dexmedetomidine.
paracetamol
Drug
Patients who were administered 50 mg paracetamol.

Treatment groups

170 Participants

are divided into 3 treatment groups

Group A: LidocaineActive comparator 1 intervention

Group B: ParacetamolExperimental treatment 1 intervention

Group C: DexmedetomidineExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

Rocuronium Withdrawal Movement Score

Score evaluating involuntary withdrawal movements in response to rocuronium injection (0 = No movement, 1 = Movement only at the wrist, 2 = Movement involving the upper arm and shoulder of the injected arm, 3 = Widespread movement in multiple extremities or full-body withdrawal)

Time frame

Immediately after rocuronium injection

Secondary outcomes

Propofol Pain Score

Score assessing the intensity of pain during propofol injection. ıt will be assessed with 11-point Visual Analog Scale (0: No pain at all, 10: Worst pain imaginable in my life).

Time frame

Immediately after propofol injection

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Baskent University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: