Optimizing Pain Control in Transurethral Resection of the Prostate

Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexMale
Age18+
SponsorBenaroya Research Institute

About this trial

The purpose of this study is to develop a multi-modal protocol for pain management after TURP that minimizes opioid use. The investigators hypothesize this approach will provide non-inferior pain control to the current standard of care which includes opioids as the primary agent. The investigators believe this is an important step in reducing the opioid epidemic in surgical patients.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Are identified as candidates for TURP

Are 18 years of age or greater

Are proficient in English

Disqualifiers

Have filled an opioid prescription in the last 2 months

Have an allergy to a medication included in the protocol

Have a history of pelvic radiation

Have renal failure (Serum Cr > 2.0 mg/dl), peptic ulcer disease, history of gastric bypass, cirrhosis, or other contraindication precluding use of NSAID's

Trial design

Design model

Parallel

Treatments tested in this trial

  • Ibuprofen 600 mg

    Drug

    We'll be adding ibuprofen while trying to limit oxycodone use while hospitalized. Patients will not be discharged with a narcotic.

  • Education

    Behavioral

    We'll be adding education to patient's post-operative instructions to aid in their pain control management.

Treatment groups

50 Participants
are divided into 2 treatment groups
Group A: Standard of care armNo intervention 0 interventions
Group B: Multi-modal groupExperimental treatment 2 interventions

Trial outcomes

Primary outcomes

1

Opioid Consumption

Total opioid utilization

Time frame
PACU-72 hours
2

Pain Scores

Numerical Rating Scale Pain Scores (Range: 0-10, where 0 is no pain and 10 is the worst pain)

Time frame
PACU-72 hours

Secondary outcomes

1

Presence of a foley catheter at discharge.

Was the patient discharged with a Foley catheter?

Time frame
0-48hours
2

Presence of narcotic side effects

nausea/vomiting, pruritus, constipation, dizziness or feelings of sedation

Time frame
48 hours after discharge
3

Were there any post-operative complications

Any complications post-operatively that occurred in the immediate post-operative setting.

Time frame
0-48 hours

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Benaroya Research Institute

Lead sponsor

Virginia Mason Hospital/Medical Center

Collaborator