Outcomes After Planned Discontinuation of AntiSeizure Medication
ConditionEpilepsy
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Michigan
About this trial
The main purpose of this study is to understand the effects of continuing versus discontinuing antiseizure medications after a period of seizure-freedom. Physician guidelines endorse that after a period of seizure-freedom, the risk of another seizure may be low enough to allow patients to consider coming off antiseizure medication to see if they still need it. However, evidence is limited regarding how much continuing antiseizure medication still reduces seizures versus increases side effects after a patient has been treated for a while. This study will determine whether discontinuing antiseizure medications benefits patients.
Eligibility criteria
Qualifiers
Provision of signed and dated informed consent form
Stated willingness to comply with all study procedures and availability for the duration of the study
Diagnosis of epilepsy
At least 2 years since participants most recent seizure
Disqualifiers
Current pregnancy or planned pregnancy during the study period
History of epilepsy surgery
Large space-occupying radiographic lesion such as a large cortical tumor, large artery stroke, or encephalomalacia from traumatic brain injury.
Subject has any other clinically significant conditions or circumstances that in the judgment of the investigator or treating clinician should preclude study participation.
Trial design
Treatments tested in this trial
- Discontinue antiseizure medications
Treatment groups
40 Participants
are divided into 1 treatment groupSponsors and collaborators
University of Michigan
Lead sponsor
National Institute on Aging (NIA)
Collaborator
Source ClinicalTrials.gov