About this trial
The purpose of this study is to learn about the effectiveness of different pain control options after hand and wrist surgery, specifically Ketorolac, Tylenol, and a regional nerve block. Ketorolac (Toradol) is a nonsteroidal anti-inflammatory drug (NSAID) that is similar to ibuprofen (Motrin or Advil). Tylenol (acetaminophen) is a commonly used over the counter drug. A nerve block is pain medication that is applied directly to the nerves around the surgical site before the surgery and keeps working to reduce pain in the area for several hours after the surgery. All of these medicines and procedures are approved by the Food and Drug Administration (FDA) for patient care. This study aims to understand if using these medicines in combination helps patients having hand and wrist surgery avoid the need for opioid pain medications.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age 18 years or older
Undergoing upper extremity surgery performed by a hand and upper extremity orthopaedic surgeon at the University of Chicago.
Undergoing procedure with regional nerve block
Disqualifiers
Age less than 18 years
Concomitant chronic opioid use
Postoperative opioid use (surgery through POD 14) for condition other than repaired fracture
Medical contraindication to ketorolac use, including pregnancy
Trial design
Sequential
Treatments tested in this trial
Toradol
DrugRegional Nerve Block + Toradol + Acetaminophen
Oxycodone
DrugRegional Nerve Block + Oxycodone + Acetaminophen
Treatment groups
Trial outcomes
Primary outcomes
Postoperative Pain, as measured by the Numeric Pain Scale
The numerical pain rating scale is used for rating postoperative pain. Pain scores rate from 0 to 10, with higher scores indicating more severe pain.
Secondary outcomes
Opioid requirements, measured in oral morphine equivalents
Opioid requirements for breakthrough pain will be measured in Ketorolac (Toradol) group in Oral Morphine Equivalents (OME).
Sponsors and contacts
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