Pain Control With Ketorolac and Nerve Block After Wrist and Hand Surgery

Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Chicago

About this trial

The purpose of this study is to learn about the effectiveness of different pain control options after hand and wrist surgery, specifically Ketorolac, Tylenol, and a regional nerve block. Ketorolac (Toradol) is a nonsteroidal anti-inflammatory drug (NSAID) that is similar to ibuprofen (Motrin or Advil). Tylenol (acetaminophen) is a commonly used over the counter drug. A nerve block is pain medication that is applied directly to the nerves around the surgical site before the surgery and keeps working to reduce pain in the area for several hours after the surgery. All of these medicines and procedures are approved by the Food and Drug Administration (FDA) for patient care. This study aims to understand if using these medicines in combination helps patients having hand and wrist surgery avoid the need for opioid pain medications.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age 18 years or older

Undergoing upper extremity surgery performed by a hand and upper extremity orthopaedic surgeon at the University of Chicago.

Undergoing procedure with regional nerve block

Disqualifiers

Age less than 18 years

Concomitant chronic opioid use

Postoperative opioid use (surgery through POD 14) for condition other than repaired fracture

Medical contraindication to ketorolac use, including pregnancy

Trial design

Design model

Sequential

Treatments tested in this trial

  • Toradol

    Drug

    Regional Nerve Block + Toradol + Acetaminophen

  • Oxycodone

    Drug

    Regional Nerve Block + Oxycodone + Acetaminophen

Treatment groups

120 Participants
are divided into 2 treatment groups
Group A: Non-OpioidExperimental treatment 1 intervention
Group B: OpioidActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Postoperative Pain, as measured by the Numeric Pain Scale

The numerical pain rating scale is used for rating postoperative pain. Pain scores rate from 0 to 10, with higher scores indicating more severe pain.

Time frame
2 days, 1 week and 2 weeks post op

Secondary outcomes

1

Opioid requirements, measured in oral morphine equivalents

Opioid requirements for breakthrough pain will be measured in Ketorolac (Toradol) group in Oral Morphine Equivalents (OME).

Time frame
Through 2 weeks postop

Other outcomes

Sponsors and contacts

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