Premedication With Atenolol Versus Metoprolol for Controlled Hypotensive Anesthesia During Nasal Surgeries

Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age21-50
SponsorDamanhour Teaching Hospital

About this trial

Objectives: To compare the safety and efficacy of oral atenolol versus oral metoprolol as a premedication for controlled hypotensive anesthesia during nasal surgeries.

Background: Mucosal bleeding is the most frequent complication with nasal surgeries, as it interferes with the optimal visualization of the intranasal anatomy, increases operation time, and consequently increases blood loss. There are several pharmacological and non-pharmacological techniques for the appropriate control of intraoperative bleeding.

Patients and Methods: This was a prospective, randomized, double-blind, phase four, comparative clinical trial; carried out on 60 patients, who were candidates for nasal surgeries under general anesthesia at our hospital. Patients were randomly allocated into two equal groups; group A, received oral atenolol, and group M, received oral metoprolol.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

American Society of Anesthesiologists (ASA) physical status ≤ II

Age from 21 to 50 years

Disqualifiers

ASA physical status > II

Age < 21 years or > 50 years

Pregnant women

Breastfeeding

Trial design

Design model

Parallel

Treatments tested in this trial

  • Atenolol Succinate Oral Tablet

    Drug

    Atenolol 50 mg

  • Metoprolol Succinate Oral Tablet

    Drug

    Metoprolol 100 mg

Treatment groups

60 Participants
are divided into 2 treatment groups
Group A: Group A (n=30)Active comparator 1 intervention
Group B: Group M (n=30)Active comparator 1 intervention

Trial outcomes

Primary outcomes

1

Mean and Standard deviation of Blood loss (ml)(mean±SD)

Amount of blood loss at the end of surgery

Time frame
5 minutes after the end of surgery

Secondary outcomes

Other outcomes

Sponsors and contacts

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