About this trial
Objectives: To compare the safety and efficacy of oral atenolol versus oral metoprolol as a premedication for controlled hypotensive anesthesia during nasal surgeries.
Background: Mucosal bleeding is the most frequent complication with nasal surgeries, as it interferes with the optimal visualization of the intranasal anatomy, increases operation time, and consequently increases blood loss. There are several pharmacological and non-pharmacological techniques for the appropriate control of intraoperative bleeding.
Patients and Methods: This was a prospective, randomized, double-blind, phase four, comparative clinical trial; carried out on 60 patients, who were candidates for nasal surgeries under general anesthesia at our hospital. Patients were randomly allocated into two equal groups; group A, received oral atenolol, and group M, received oral metoprolol.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
American Society of Anesthesiologists (ASA) physical status ≤ II
Age from 21 to 50 years
Disqualifiers
ASA physical status > II
Age < 21 years or > 50 years
Pregnant women
Breastfeeding
Trial design
Parallel
Treatments tested in this trial
Atenolol Succinate Oral Tablet
DrugAtenolol 50 mg
Metoprolol Succinate Oral Tablet
DrugMetoprolol 100 mg
Treatment groups
Trial outcomes
Primary outcomes
Mean and Standard deviation of Blood loss (ml)(mean±SD)
Amount of blood loss at the end of surgery
Sponsors and contacts
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