Preoperative Acetazolamide
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexFemale
Age21-65
SponsorPrisma Health-Upstate
About this trial
The goal of this randomized study looks at whether giving patients a medicine called acetazolamide (also called Diamox) before they have laparoscopic hysterectomy may decrease postoperative pain. Researchers will compare acetazolamide to a placebo or inactive drug, to see if acetazolamide helps the pain that may occur after surgery from the gas used in the abdomen during the laparoscopic procedure. Patients will be asked to rate their pain before surgery and after surgery through 24 hours.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Women
Ages 21-65
undergoing total laparoscopic hysterectomy (TLH) for benign indications with or without bilateral salpingoophorectomy
undergoing total laparoscopic hysterectomy (TLH) for benign indications with or without cystoscopy
Disqualifiers
Allergy to acetazolamide or sulfonamides
Known electrolyte disturbances
Pregnancy
Kidney failure or creatinine >1.5
Trial design
Design model
Parallel
Treatments tested in this trial
Acetazolamide 500 MG Extended Release Oral Capsule
DrugActive Drug
Placebo
DrugInactive Drug
Treatment groups
100 Participants
are divided into 2 treatment groupsGroup A: Active DrugActive comparator 1 intervention
Group B: PlaceboActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
Abdominal/pelvic pain and right subscapular pain rated on a VAS at five perioperative points
Baseline score at preoperative time point and 4 time points post operative
Time frame
From before procedure to 24 hours post procedure2
Total analgesic use postoperatively
analgesic use in the post operative period will be calculated in morphine equivalents
Time frame
from end of procedure to 24 hours post procedureSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov