To determine whether regulating the gut microbiota can contribute to the eradication of refractory H. pylori infection.
1. Ages 18-70
2. Hp infection treatment failed ≥4 times with guidelines-recommended therapies
3. Patients with early gastric cancer, peptic ulcer, gastric MALT lymphoma, atrophic gastritis and other diseases requiring the eradication of Hp.
1. Antibiotics and bismuth were taken within 4 weeks before this treatment; Or had taken PPI, H2 receptor antagonist, P-CAB within 2 weeks prior to treatment;
2. Pregnant or lactating women;
3. Those who are allergic to the investigational drugs used in this test or have contraindications;
4. Participated in other drug trials within 3 months before the treatment of this trial;