The Effect of Different Antibiotic Protocols on Peri-implant Tissue Health
ConditionAntibiotic
Trial statusNot yet recruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age35-65
SponsorUniversita degli Studi di Genova
About this trial
The aim of the present project (non-inferiority trial) is to evaluate the effect of different antibiotic strategies (long-span vs. short-span) for implant surgery on peri-implant tissue health, oral microbiome (included resistome) and salivary MiRNomics in healthy patients.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
None
Disqualifiers
Patients unable to commit to follow-up
General contraindications to implant surgery
Immuno-suppressed/immune-compromised patients
Patients irradiated in the head and/or neck
Trial design
Design model
Parallel
Treatments tested in this trial
Amoxicillin Short
DrugShort Span
Amoxicillin Long
DrugLong span
Treatment groups
80 Participants
are divided into 2 treatment groupsGroup A: Long-span therapyExperimental treatment 1 intervention
Group B: Short-span therapyExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Mean peri-implant bone loss
bone loss
Time frame
at 6 and 12 months after prosthesis deliverySecondary outcomes
1
Incidence of biological and technical complications at the implant site
complications
Time frame
12 months2
implant survival rate
CSR
Time frame
12 months3
Antibiotic sensitivity
sensitivity
Time frame
1 week before and 2 months and 6 months after implant insertion4
Peri-implant myco-, microbiome and resistome
resistome
Time frame
1 week before and 2 months and 6 months after implant insertionLocations
Sponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: