Under the premise of basic treatment, to explore the improvement effect of huperzine A injection on short-term and long-term neurocognitive dysfunction in patients with aneurysmal subarachnoid hemorrhage after interventional/surgical treatment.
Age 18-70;
The patients were proved to be aneurysmal subarachnoid hemorrhage by imaging examination (head CT, CT angiography (CTA), whole brain angiography (DSA));
Hunt Hess was graded I-III at admission;
The patients were treated with endovascular therapy or craniotomy and clipping surgery;
Non aneurysmal subarachnoid hemorrhage;
Cognitive dysfunction existed before onset;
Patients with angina pectoris, bronchial asthma, mechanical intestinal obstruction, liver and kidney insufficiency, and urinary tract obstruction;
Complicated with other nervous system diseases, including nervous system degenerative diseases (Alzheimer's disease, Parkinson's disease, Lewy body dementia, frontotemporal dementia, etc.), neuromyelitis optica, epilepsy, central nervous system infection (such as AIDS, syphilis, etc.), brain traumatic dementia, etc;
Parallel
Huperzine A injection, operational treatment, the best basic treatment
Drugintramuscular
operational treatment, the best basic treatment
Other interventionother
Huperzine A injection, interventional treatment, the best basic treatment
Drugintramuscular
Interventional treatment, the best basic treatment
Other interventionother
Mini Mental Status Examination（MMSE ）
The seven items in the scale were used for scoring, and the degree of intellectual status and cognitive impairment before treatment, during follow-up and after treatment were compared within and between groups. The higher the score, the better the intellectual state of the subjects.
Hospital anxiety and depression Scale（HADS）
The anxiety and depression subscales of the Hospital Anxiety and Depression Scale were used to screen the anxiety and depression of the subjects before treatment, at the end of medication and at the visit period after discharge, and the intra group and inter group comparisons were made. The higher the score, the more serious the anxiety or depression.
The Short Form-36 Health Survey
Calculate the eight items in the scale. Before and after treatment, the scores of each items and the total score of body and psychology were compared within and between groups.
Modified Rankin Score
The functional recovery outcomes before treatment, at the end of medication and at the visit period after discharge were evaluated by using the modified Rankin scale, and compared within and between groups. The higher the score, the worse the functional recovery.
Biological sample detection
Biological samples were tested during the screening period, during the medication period, and after the medication period to obtain drug metabolomics analysis data and disease biomarker data, and intra-group and inter-group comparisons were performed.
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Wanbangde Pharmaceutical Group Co., LTD
Lead sponsor
Second Affiliated Hospital, Zhejiang University, School of Medicine
Collaborator
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