Health TrialsbyHealthPanel

The Impact of GLP Medication on Colonoscopy Bowel Preparation Quality

ConditionsGLP - 1Bowel Preparation for Colonoscopy
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorThe Cleveland Clinic

About this trial

The goal of this clinical trial is to learn how GLP-1 and GIP agonists effect bowel preparation in patients scheduled for colonoscopies. The main questions it aims to answer are:

* Does GLP-1 and GIP agonist increase the rate of inadequate bowel preparation? * Does the quality of bowel preparation differ in patients who hold vs. those who continue a single dose of their GLP-1 or GIP agonist medication? * Are there any differences in the rates of complications gastric aspiration in patients who hold vs. continue a single dose of their GLP-1 or GIP agonist medication?

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Adult patient (Age 18 years or older)

Patient scheduled for outpatient screening, surveillance, or diagnostic colonoscopy

Using a GLP-1 or GIP agonist at a stable dose for at least one month

Disqualifiers

Unable to provide informed consent, e.g., dementia

Patient refuses the USMSTF recommended bowel cleansing regimen for patients with diabetes or obesity (split-dose 4 liters polyethylene glycol + 15 mg bisacodyl the afternoon before; low residue diet 3 days before colonoscopy; clear liquid diet the day before colonoscopy)

Cirrhosis

Parkinson's disease

Trial design

Design model

Parallel

Treatments tested in this trial

  • Continue GLP/GIP

    Drug

    Continue GLP-1 or GIP-based therapy as prescribed prior to the procedure.

Treatment groups

132 Participants
are divided into 2 treatment groups
Group A: Continue GLP/GIP medicationActive comparator 1 intervention
Group B: Hold medicationNo intervention 0 interventions

Trial outcomes

Primary outcomes

1

Rate of inadequate bowel preparation

Time frame
During Surgery

Secondary outcomes

1

Median Boston bowel prep score

Time frame
During Surgery
2

Median Ottawa bowel preparation score

Time frame
During Surgery
3

Adenoma detection rate

Time frame
During Surgery
4

Colonoscope Insertion time

Time it takes to reach the cecum

Time frame
During Surgery

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

The Cleveland Clinic

Lead sponsor

Source ClinicalTrials.gov
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