These Studies That Evaluated the Efficacy of Antibiotics for Leptospirosis Treatment.
Trial statusNot yet recruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorChulalongkorn University
About this trial
The goal of this randomized controlled trial is to study antibiotic chemoprophylaxis to prevent leptospirosis of high-risk populations.
The main question it aims to answer is : Does the efficacy of chemoprophylaxis regimens to prevent prevent leptospirosis?
Eligibility criteria
This trial accepts healthy volunteersQualifiers
High-risk exposure typically refers to water or soil - particularly wet ground at workplace and/or contact with animal water reservoir
Disqualifiers
Body temperature higher than 38 °C
Patients were confirmed to have leptospirosis within 3 months
Pregnancy or breastfeeding
Allergy to doxycycline
Trial design
Design model
Crossover
Treatments tested in this trial
Doxycycline
DrugDoxycycline 200 mg weekly
Placebo
DrugPlacebo
Treatment groups
1,000 Participants
are divided into 2 treatment groupsGroup A: Doxycycline 200 mg weekly doseExperimental treatment 1 intervention
Group B: PlaceboPlacebo comparator 1 intervention
Trial outcomes
Primary outcomes
1
Incidence of Leptospira infection
Number of leptospirosis cases based on Polymerase Chain Reaction (PCR), culture and Microscopic Agglutination Test (MAT)
Time frame
1 monthLocations
Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: