Use of Adenosine to Determine the Electrophysiological Mechanism of Premature Ventricular Contractions

ConditionPremature Ventricular Contraction (PVC)

Trial statusRecruiting

Trial phasePhase 4

Trial typeInterventional

Biological sexAll

Age18-70

SponsorWeill Medical College of Cornell University

About this trial

Unblinded, controlled, non-randomized, mechanistic study to determine whether physiological mechanisms underlying PVC are sensitive to adenosine. One hundred subjects undergoing clinically-indicated, standard-of-care cardiac electrophysiology study (EPS) procedure for PVCs will receive adenosine and/or verapamil to learn if their arrhythmias are inducible similarly to sustained ventricular tachycardia.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Diagnosis of premature ventricular contractions (PVCs)

Scheduled to undergo an electrophysiology study with the intention of performing cardiac ablation for the treatment of PVCs

Male or female between the ages of 18 and 70 years

Capable of giving informed consent

Disqualifiers

Any structural heart disease

Coronary artery disease (≥ 70% stenosis)

Current treatment with anti-arrhythmic drugs

Pregnant

Trial design

Design model

Single group

Treatments tested in this trial

Adenosine
Drug
Adenosine: 0.84 mg/kg (140 mcg/kg/minute IV for 6 minutes) Verapamil 0.15 mg/kg

Treatment groups

100 Participants

are divided into 1 treatment group

Group A: Adenosine/ Verapamil ArmOther 1 intervention

Trial outcomes

Primary outcomes

Effects of Adenosine on premature ventricular contractions (PVCs) as measured by EKG;

The metrics that will be collected will be: * Baseline frequency of premature ventricular contractions (PVCs) * Frequency of premature ventricular contractions (PVCs) during adenosine administration

Time frame

baseline

Effects of verapamil on premature ventricular contractions (PVCs) as measured by EKGs.

The metrics that will be collected will be: * Baseline frequency of premature ventricular contractions (PVCs) * Frequency of premature ventricular contractions (PVCs) during verapamil administration

Time frame

baseline

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Weill Medical College of Cornell University

Lead sponsor

Source ClinicalTrials.gov

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