About this trial
The aim is to evaluate the safety and efficacy of vunakizumab combined with recaticimab versus vunakizumab combined with placebo in the treatment of plaque psoriasis with dyslipidemia.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
None
Disqualifiers
Use of TNF-α, IL-12/23, IL-17, or IL-23 monoclonal antibodies (e.g., adalimumab, ustekinumab, ixekizumab, secukinumab, guselkumab) within 3 months prior to screening;
Use of systemic psoriasis treatments (including but not limited to methotrexate, JAK inhibitors, acitretin, cyclosporine, oral or injectable corticosteroids) within 4 weeks prior to screening;
Use of topical psoriasis treatments (including but not limited to corticosteroids, vitamin D₃ analogues, calcineurin inhibitors, tapinarof) within 2 weeks prior to screening;
Receipt of phototherapy (including oral or topical PUVA, UVB, tanning beds, or therapeutic sun exposure) within 4 weeks prior to screening;
Trial design
Parallel
Treatments tested in this trial
vunakizumab and recaticimab.
DrugAdult patients (\>18 years) with moderate-to-severe psoriasis who will start treatment with either vunakizumab and recaticimab.
vunakizumab and placebo
DrugAdult patients (\>18 years) with moderate-to-severe psoriasis who will start treatment with either vunakizumab and placebo.
Treatment groups
Trial outcomes
Primary outcomes
PASI 100 response rate at week 16 in the group treated with vunakizumab combined with recaticimab versus vunakizumab combined with placebo
Locations
Sponsors and contacts
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This trial is not recruiting at the moment. You can still explore other options: