This study plans to learn about heart function among individuals with chronic obstructive pulmonary disease (COPD). In particular, the investigators want to understand the different patterns of right ventricular response during rest and moderate- vs high-intensity exercise. By identifying patterns of right ventricular dysfunction, this study will help identify better treatments for patients with COPD in the future.
COPD (determined by ratio of forced expiratory volume in 1 second to forced vital capacity [FEV1/FVC] <0.7)
Age >= 40 years
Exacerbation of COPD in the 3 months prior to enrollment
Change in COPD therapy in the 3 weeks prior to enrollment
Requirement of >6 LPM supplemental oxygen at rest
Requirement of >10 LPM supplemental oxygen with exertion
Single group
Exercise
BehavioralAfter a brief warmup, participants will be asked to perform approximately 5 minutes of exercise at moderate intensity and then approximately 2 minutes of exercise at high intensity.
Right ventricular contractility measured by transthoracic echocardiography
Global longitudinal strain, measured in absolute percent
Right ventricular contractility measured by conductance catheter
Maximum rate of pressure change, dP/dtmax in mmHg/sec
Right ventricular systolic function measured by transthoracic echocardiography
Fractional area change on transthoracic echocardiography, measured in percent
Right ventricular systolic function measured by transthoracic echocardiography
Tricuspid annular plane systolic excursion on transthoracic echocardiography, measured in centimeters
Health-related quality of life by Short Form 36 (SF-36) questionnaire
Units, range 0-100 with greater scores indicating a more favorable health state
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