This double-blind, randomized, sham-controlled clinical trial aims to evaluate the effects of vascular photobiomodulation on blood pressure and vascular function in hypertensive patients treated with losartan. A total of 80 patients using losartan (100 mg/day for at least two months) will be recruited and followed for 4 weeks. Participants will be randomly allocated to either an active photobiomodulation group or a sham control group.
Be taking losartan at a dose of 100 mg/day, either as monotherapy or in combination with other antihypertensive medications, administered in two divided doses, for a minimum of 2 months and a maximum of 24 months.
Present systolic blood pressure is less than or equal to 140 mmHg and diastolic less than or equal to 90 mmHg.
Not having used any other antihypertensive medication in the last 2 months.
Age between 18 and 65 years
Changes in medication status during the study
Parallel
Vascular Photobiomodulation
DeviceVascular photobiomodulation therapy applied over the radial artery using a red laser (wavelength: 660 nm; power: 100 mW).
Sham Photobiomodulation
DeviceLaser emission will be blocked to ensure no therapeutic effect
Change in Brachial Artery Vascular Function
Flow-mediated dilation (FMD, %) of the brachial artery assessed by Doppler ultrasound. Higher values indicate better endothelial function
Change in Resting Systolic and Diastolic Blood Pressure
Systolic and diastolic blood pressure (mmHg) measured under standardized resting conditions using validated automated devices. Lower values indicate improvement
Acute Change in Brachial Artery Vascular Function
Flow-mediated dilation (FMD, %) of the brachial artery assessed by Doppler ultrasound before and after the intervention session, following current guidelines. Higher values indicate better endothelial function
Acute Change in Resting Blood Pressure
Systolic and diastolic blood pressure (mmHg) measured immediately before and after the intervention session using validated automated devices.
Change in Residential Blood Pressure
Mean systolic and diastolic blood pressure (mmHg) obtained during one week through residential blood pressure monitoring using validated devices and standardized protocols across the intervention period. Lower values indicate improvement.
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