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Physical Activity Program for Reducing Blood Pressure in Sleep Apnea Patients With Resistant Hypertension

ConditionsHypertension, Resistant to Conventional TherapySleep Apnea
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorAGIR à Dom

About this trial

Investigators hypothesize that CPAP treatment for suppressing OSAS in combination with a physical activity program will optimize 24-hour blood pressure control in patients with OSA-related resistant hypertension.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Patient with an obstructive sleep apnea (apnea-hypopnea index > or equal to 15)

Patient with resistant hypertension uncontrolled by 3 or more antihypertensive agents

Ambulatory patient

Disqualifiers

Acute hepatic failure, biliary cirrhosis, cholestasis

Acute hypertension (SBP>= 180 mmHg and/or DBP >= 110 mmHg)

Contraindication to CPAP treatment

Trial design

Design model

Parallel

Treatments tested in this trial

  • Physical activity

    Other intervention

    Physical activity will carry out 3 times per week during 12 weeks for intervention arm

Treatment groups

100 Participants
are divided into 2 treatment groups
Group A: Physical activityExperimental treatment 1 intervention
Group B: Control GroupNo intervention 0 interventions

Trial outcomes

Primary outcomes

1

Systolic arterial blood pressure assessed by 24-hours home blood pressure monitoring

Systolic arterial blood pressure assessed by 24-hours home blood pressure monitoring

Time frame
To baseline at 12 weeks

Secondary outcomes

1

diastolic arterial blood pressure assessed by 24-hours home blood pressure monitoring

diastolic arterial blood pressure assessed by 24-hours home blood pressure monitoring

Time frame
To baseline at 12 weeks
2

Mean arterial blood pressure assessed by 24-hours home blood pressure monitoring

Mean arterial blood pressure assessed by 24-hours home blood pressure monitoring

Time frame
To baseline at 12 weeks
3

Change in physical activity: number of hour per day of physical activity

Change in physical activity: number of hour per day of physical activity

Time frame
To baseline at 12 weeks
4

pulse wave velocity

pulse wave velocity

Time frame
To baseline at 12 weeks

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

AGIR à Dom

Lead sponsor

University Hospital, Grenoble

Collaborator

Source ClinicalTrials.gov
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