About this trial
The goal of this clinical trial is to evaluate the impact of Physical Exercise (PE), as an adjuvant treatment, on the cognition of patients diagnosed with Bipolar Disorder who present cognitive impairments, as well as its impact on quality of life and functionality and its association with physiological variables.
Our specific goals are:
1. Evaluate the effect of PE on the neuropsychological functions of attention, memory, verbal fluency, executive function and processing speed in patients diagnosed with BD who present cognitive impairments in these domains. 2. To evaluate the effect of PE on the quality of life and functionality of patients diagnosed with BD, as well as possible associations with cognitive functions. 3. To evaluate possible correlations between physiological variables, such as cardiorespiratory indices, strength and body composition, and improvements in cognitive functions, quality of life and functionality.
Eligibility criteria
Qualifiers
Diagnosis of Bipolar disorder (BD) I and II according to DSM-5
Age: 18 - 55 years old
Complete primary education
Euthymic (YMRS < 8 and MADRS < 12)
Disqualifiers
Organic mental disorder
BMI > 40
Alcohol or drug abuse in the last 6 months
Use of benzodiazepines or beta-blockers in the last month
Trial design
Treatments tested in this trial
- Physical Exercise
Treatment groups
Sponsors and collaborators
Beny Lafer
Lead sponsor
University of Sao Paulo
Sponsor institution