Physical Exercise for Cognitive Rehabilitation of Patients With Bipolar Affective Disorder

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-60
SponsorBeny Lafer

About this trial

The goal of this clinical trial is to evaluate the impact of Physical Exercise (PE), as an adjuvant treatment, on the cognition of patients diagnosed with Bipolar Disorder who present cognitive impairments, as well as its impact on quality of life and functionality and its association with physiological variables.

Our specific goals are:

1. Evaluate the effect of PE on the neuropsychological functions of attention, memory, verbal fluency, executive function and processing speed in patients diagnosed with BD who present cognitive impairments in these domains. 2. To evaluate the effect of PE on the quality of life and functionality of patients diagnosed with BD, as well as possible associations with cognitive functions. 3. To evaluate possible correlations between physiological variables, such as cardiorespiratory indices, strength and body composition, and improvements in cognitive functions, quality of life and functionality.

Eligibility criteria

Qualifiers

Diagnosis of Bipolar disorder (BD) I and II according to DSM-5

Age: 18 - 55 years old

Complete primary education

Euthymic (YMRS < 8 and MADRS < 12)

Disqualifiers

Organic mental disorder

BMI > 40

Alcohol or drug abuse in the last 6 months

Use of benzodiazepines or beta-blockers in the last month

Trial design

Treatments tested in this trial

  • Physical Exercise

Treatment groups

72 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Beny Lafer

Lead sponsor

University of Sao Paulo

Sponsor institution