Physical Fitness and Hot Executive Function in Alzheimer's Risk
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age50-70
SponsorNational Taiwan Normal University
About this trial
This 18-month study tracks how physical fitness relates to executive function in older adults, aiming to determine if fitness improvements predict better cognitive performance. Participants complete assessments at baseline and 18 months, including cardiorespiratory fitness (YMCA bike test), muscle strength (chest and leg press tests), and executive function (computer tasks with brain activity recording via EEG). Additional measures include physical activity questionnaires, cognitive screening (MMSE), memory tests (digit span), demographics (age, sex, education), and blood tests for APOE ε4 gene status. No exercise program will be provided, allowing observation of natural fitness-cognition relationships in daily life.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Age 50-70.
Able to engage in fitness testing.
Normal vision or corrected-to-normal vision.
Disqualifiers
Suffering from cardiopulmonary-related diseases.
Suffering from cognitive, neurological or psychiatric disorders (e.g., dementia, Parkinson's disease, epilepsy, depression, schizophrenia, etc.).
Suffering from infectious diseases (e.g., hepatitis, human immunodeficiency virus or Creutzfeldt-Jakob disease).
Having a history of drug or alcohol abuse.
Trial population
The study population is older adults aged 50-70.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
observation alone
Other interventionNo interventions will be conducted during the observation period, maintaining participants' normal daily living conditions.
Treatment groups
240 Participants
are divided into 1 treatment groupGroup A: Older adults1 intervention
Trial outcomes
Primary outcomes
1
Changes in cardiorespiratory fitness
Cardiorespiratory fitness will be estimated using the YMCA submaximal cycle ergometer test at baseline (Baseline Assessment) and at the 18-month follow-up (Post Assessment). Changes in cardiorespiratory fitness between the Baseline and Post Assessments will be evaluated.
Time frame
Approximately 25 minutes each at the baseline assessment and the 18-month follow-up post-assessment.2
Changes in muscular fitness
Muscular fitness will be assessed via a standardized 8-10 repetition maximum protocol on chest-press and leg-press machines at baseline (Baseline Assessment) and at the 18-month follow-up (Post Assessment). Changes in muscular fitness between the Baseline and Post Assessments will be evaluated.
Time frame
Approximately 25 minutes each at the baseline assessment and the 18-month follow-up post-assessment3
Change in cognitive flexibility-response time
Cognitive flexibility will be assessed via a task-switching test at baseline (Baseline Assessment) and at the 18-month follow-up (Post Assessment). Changes in response times on the task-switching test between Baseline and Post Assessments will be analyzed.
Time frame
Approximately 30 minutes each at the baseline assessment and the 18-month follow-up post-assessment4
Change in cognitive flexibility-adcuracy
Cognitive flexibility will be assessed via a task-switching test at baseline (Baseline Assessment) and at the 18-month follow-up (Post Assessment). Changes in accuracy on the task-switching test between Baseline and Post Assessments will be analyzed.
Time frame
Approximately 30 minutes each at the baseline assessment and the 18-month follow-up post-assessmentSecondary outcomes
1
Cognitive function (Mini-Mental State Examination, MMSE)
The Mini-Mental State Examination (MMSE), a 30-item cognitive screening tool yielding a total score of 0-30, will be administered at baseline (Baseline Assessment) and at the 18-month follow-up (Post Assessment). Changes in MMSE total scores between Baseline and Post Assessments will be analyzed.
Time frame
Approximately 15 minutes each at the baseline assessment and the 18-month follow-up post-assessment2
Working memory (Digit Span Tests)
Working memory will be assessed via the Digit Span subtest of the Wechsler Adult Intelligence Scale - Third Edition (WAIS-III), in which participants verbally reproduce auditorily presented digit sequences in their original (forward) or reverse (backward) order, at baseline (Baseline Assessment) and at the 18-month follow-up (Post Assessment). Changes in MMSE total scores between Baseline and Post Assessments will be analyzed.
Time frame
Approximately 15 minutes each at the baseline assessment and the 18-month follow-up post-assessment3
ApoE genotype
Apolipoprotein E (ApoE) genotype will be determined for each participant by genotyping the single nucleotide polymorphisms rs429358 and rs7412.
Time frame
5 minutes at the Baseline Assessment4
Physical activity (Taiwan version of the International Physical Activity Questionnaire, IPAQ)
Physical activity will be assessed via the Taiwanese version of the International Physical Activity Questionnaire-Short Form (IPAQ-SF) at baseline (Baseline Assessment) and at the 18-month follow-up (Post Assessment). Changes in IPAQ-SF scores between Baseline and Post Assessments will be analyzed.
Time frame
Approximately 15 minutes each at the baseline assessment and the 18-month follow-up post-assessmentSponsors and contacts
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Source ClinicalTrials.gov