Physiological Effects of Lung Impedance Tomography-Guided and Plat Pressure-Guided Phigh During APRV in Patients With ARDS
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorXiaoJing Zou,MD
About this trial
This study aims to investigate the effects of EIT-guided and Pplat-guided Phigh settings on regional ventilation and perfusion in ARDS patients during APRV, while also examining the impact of different Phigh settings on gas exchange, respiratory mechanics, and hemodynamics.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Diagnosed with ARDS according to the 2023 global new definition of ARDS.
Age ≥ 18 years.
Disqualifiers
Severe chronic obstructive pulmonary disease, severe asthma, pulmonary bullae, pneumothorax, subcutaneous emphysema, mediastinal emphysema, etc. · Contraindications for EIT, such as chest wound dressing, pacemaker implantation, defibrillator use, etc.
Pulmonary interstitial disease.
Uncorrected shock of various types.
Intracranial hypertension.
Trial design
Design model
Crossover
Treatments tested in this trial
EIT-guided Phigh settings during APRV
DeviceThe Phigh level selected for the patients in the Intervention group was the intercept point of cumulated collapse and overdistension percentage curves, providing the best compromise between collapsed and overdistended lung.
Treatment groups
26 Participants
are divided into 2 treatment groupsGroup A: Intervention groupExperimental treatment 1 intervention
Group B: Control groupNo intervention 0 interventions
Trial outcomes
Primary outcomes
1
The effects of Phigh guided by different methods on regional lung ventilation assessed by EIT
Time frame
1 Hour Post-InterventionSecondary outcomes
1
Global inhomogeneity assessed by electrical impedance tomography
Time frame
1 Hour Post-Intervention2
Center of ventilation assessed by electrical impedance tomography
Time frame
1 Hour Post-Intervention3
ventilation/perfusion matching assessed by EIT
Time frame
1 Hour Post-Intervention4
Respiratory system compliance
Tidal volume divided by plateau pressure
Time frame
1 Hour Post-InterventionSponsors and contacts
Click on the lead sponsor to view all of their trials.
XiaoJing Zou,MD
Lead sponsor
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Sponsor institution
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Collaborator
Source ClinicalTrials.gov