The primary objectives of this study are to determine whether exercise training is an effective strategy for treatment of Long COVID and characterize the cardiorespiratory and autonomic physiology in these patients to precisely characterize mechanisms contributing to this syndrome.
Adults ≥18 years with documented history of COVID-19 infection and symptoms consistent with Long COVID lasting >12 weeks after diagnosis.
History of cardiovascular/pulmonary disease prior to infection
COVID-related myocardial injury such as evidence of myocarditis
Deep vein thrombosis/pulmonary embolism following COVID-19 infection
Exercise intolerance resulting from conditions that are not related to cardiorespiratory or autonomic factors (e.g. osteoarthritis or other musculoskeletal diseases);
Single group
Exercise
Behavioralexercise protocol
Characterizing the impact of exercise training (cardiac rehabilitation) on functional capacity among patients with Long COVID
functional capacity as determined by VO2max
Characterizing the impact of exercise training (cardiac rehabilitation) on HRqOL among patients with Long COVID
Health-related quality of life (HRqOL) from SF-36 form; all items are scored so that a high score defines a more favorable health state. In addition, each item is scored on a 0 to 100 range so that the lowest and highest possible scores are 0 and 100, respectively.
orthostatic challenge
Heart rate during orthostatic challenge
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