Platelet-Rich Fibrinogen in Extraction Socket Healing of the Aged
ConditionEdentulism
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age14-80
SponsorUniversity of Nebraska
About this trial
The purpose of this study is to better understand oral wound healing in the aged participant following placement of platelet-rich fibrinogen (PRF). In this study, 12 participants requiring a posterior tooth extraction will be enroll: 6 participants aged 14-18, 6 participants aged 50-80. All will undergo a posterior tooth extraction with a small tissue specimen taken from the extraction site. Half of the participants will also have their blood drawn and platelet-rich fibrinogen placed in the extraction socket. Participants will return in 2 weeks for suture removal and another soft tissue sample. Participants will return at 3 months for a final post-operative radiograph. All soft tissue samples will undergo immunofluorescence.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patient at University of Nebraska Medical Center (UNMC) College of Dentistry
Requires extraction of posterior tooth
Able and willing to provide consent/assent
Disqualifiers
Systemic conditions that delay wound healing
Chronic use of non-steroidal anti-inflammatory drugs (NSAIDs), methotrexate, bisphosphonates or other drugs that inhibit wound healing Smoking and vaping Pregnancy
Trial design
Design model
Parallel
Treatments tested in this trial
Platelet-rich fibrin (PRF)
Procedure/SurgeryPlatelet-rich fibrin added to extraction socket
Treatment groups
12 Participants
are divided into 4 treatment groupsGroup A: Aged Participants Treated with Platelet-rich FibrinogenActive comparator 1 intervention
Group B: Aged ControlNo intervention 0 interventions
Group C: Young Participants Treated with Platelet-rich FibrinogenActive comparator 1 intervention
Group D: Young ControlNo intervention 0 interventions
Trial outcomes
Primary outcomes
1
Cytokine Concentration
Indirect immunofluorescent intensity will determine concentration of cytokines present in sample.
Time frame
Baseline and two weeks post-extractionSecondary outcomes
1
Bone Density
Bone density as measured through cone beam computed tomography (CBCT) and Hounsfeld units will determine density of new bone formation.
Time frame
3 months post-extractionSponsors and contacts
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Source ClinicalTrials.gov