This single-center observational study aims to assess the effects of continuous high-frequency oscillation (CHFO) and continuous positive expiratory pressure (CPEP) therapy on lung recruitment using electrical impedance tomography (EIT) in spontaneously breathing patients admitted to the intensive care unit.
Patients who require pulmonary expansion and airway clearing as per clinical indication
Patients who provide valid informed consent according to local regulations
PaO2/FiO2 < 200 mmHg at inclusion
Patient on the Airway Care Score (ACS) < 7
Refuse to participate
Age < 18 years
Hemodynamic instability, defined as systolic arterial pressure < 90 mmHg or mean pressure < 60 mmHg
Contraindication to using an EIT (i.e., pacemaker or defibrillator)
Patients who are spontaneously breathing and admitted to the intensive care unit
Case-crossover
Prospective
Continuous high-frequency oscillation (CHFO) and continuous positive expiratory pressure (CPEP) therapy
Procedure/SurgeryDuring application of CPEP and CHFO, EIT is monitored.
To assess changes in systemic oxygenation
Arterial partial pressure of oxygen (PaO2, mmHg) and PaO2/FiO2 ratio (mmHg)
Changes in lung recruitment using EIT
Absolute reduction in the percentage (%) of lung volume collapse assessed with the electrical impedance tomography (EIT)
Mean arterial pressure, mmHg
Heart rate as measured by continuous pressure monitoring
Heart rate min-1
Heart rate as measured by continuous electrocardiogram monitoring
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University of Genova
Lead sponsor
Denise Battaglini
Collaborator
This trial is not recruiting at the moment. You can still explore other options:
