About this trial
to examine the relationship between repeated concussions and late decline of brain function. In addition, all participants agreeing to participate in the study will be asked to will their brains to The Krembil Neuroscience Centre Concussion Project at the Toronto Western Hospital with the consent and full knowledge of their families and doctors. However, it is possible to participate in the research without agreeing to a brain donation.
The Project Team is specifically attempting a clinical-MRI-brain tissue research analysis to determine the exact mechanism of the damage to brain tissue following repeated concussions. This condition is known as chronic traumatic encephalopathy (CTE), and shows an abnormal protein in the brain called tau-protein.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
None
Disqualifiers
None
Trial population
Retired professional athletes with history or multiple concussions and healthy control group without any history of concussion
Trial design
Case-control
Prospective
Treatments tested in this trial
Biomarkers for detecting possible CTE invivo
Diagnostic testDetection biomarkers for possible CTE: Imaging/blood/CSF/PET-tau/MRI/europsychological assessment
Treatment groups
Trial outcomes
Primary outcomes
Biomarkers for possible CTE
Neuropsychological/MRI/genetics/CSF/PET-tau/oculomotor
Sponsors and contacts
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University Health Network, Toronto
Lead sponsor
The Weston A. Price Foundation
Collaborator