Post-Concussion Syndrome in Professional Athletes: A Multidisciplinary Study

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexMale
Age25-85
SponsorUniversity Health Network, Toronto

About this trial

to examine the relationship between repeated concussions and late decline of brain function. In addition, all participants agreeing to participate in the study will be asked to will their brains to The Krembil Neuroscience Centre Concussion Project at the Toronto Western Hospital with the consent and full knowledge of their families and doctors. However, it is possible to participate in the research without agreeing to a brain donation.

The Project Team is specifically attempting a clinical-MRI-brain tissue research analysis to determine the exact mechanism of the damage to brain tissue following repeated concussions. This condition is known as chronic traumatic encephalopathy (CTE), and shows an abnormal protein in the brain called tau-protein.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

None

Disqualifiers

None

Trial population

Retired professional athletes with history or multiple concussions and healthy control group without any history of concussion

Trial design

Design model

Case-control

Time perspective

Prospective

Treatments tested in this trial

  • Biomarkers for detecting possible CTE invivo

    Diagnostic test

    Detection biomarkers for possible CTE: Imaging/blood/CSF/PET-tau/MRI/europsychological assessment

Treatment groups

150 Participants
are divided into 2 treatment groups
Group A: Former concussed pro-athletes1 intervention
Group B: Healthy controls1 intervention

Trial outcomes

Primary outcomes

1

Biomarkers for possible CTE

Neuropsychological/MRI/genetics/CSF/PET-tau/oculomotor

Time frame
several visits every two years up to 10 years

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University Health Network, Toronto

Lead sponsor

The Weston A. Price Foundation

Collaborator