Post-Emergency Optimization of Antibiotic Therapy for Urinary Tract Infection (UTI)
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorCentre Hospitalier Intercommunal Creteil
About this trial
Prospective, multicenter, non-interventional study conducted over 6 months, including patients presenting to the emergency department with suspected urinary tract infection managed as outpatients and discharged with or without empiric antibiotic therapy.
Discharge antibiotic prescriptions are reviewed, with subsequent reassessment and optimization of treatment based on urine culture and susceptibility results
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age 18 years or over
Patients presenting at emergency department, with symptoms suggestive of a urinary tract infection suitable for outpatient management (uncomplicated cystitis or cystitis at risk of complications, uncomplicated pyelonephritis or pyelonephritis at risk of complications, male urinary tract infection with or without fever) who have had a urine culture taken
Disqualifiers
Refusal to participate in the study
Vulnerable person (person under guardianship or trusteeship, minor, person deprived of liberty, person unable to express their refusal)
Pregnant women
Severe urinary tract infection (sepsis, septic shock or requiring drainage, except for low urinary catheterisation)
Trial population
Inclusion of patients presenting with suspected outpatient urinary tract infections, to the emergency department
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Adaptation of antibiotics therapy for outpatient urinary infection following emergency care
Other interventionRe assessment of antibiotic therapy at 48 hours based on urine culture results : discontinuation or de-escalation to a narrower-spectrum agent
Treatment groups
330 Participants
are divided into 1 treatment groupGroup A: Suspected of outpatient urinary tract infection1 intervention
Trial outcomes
Primary outcomes
1
Assess changes in fluoroquinolone and third-generation cephalosporin prescribing in outpatient urinary tract infections following adjustment based on urine culture and susceptibility results.
Time frame
At 48 hours - 72 hours after the patient inclusionSecondary outcomes
1
Incidence (percentage) of adverse effects associated with antibiotics.
Time frame
At 1 month after the consultation in the Emergency department2
Incidence (percentage) of antibiotic prescription savings in the Emergency department for outpatient urinary tract infections (cessation of prescription, shortening of treatment duration and/or narrowing of the spectrum) following the intervention
Time frame
At 48 hours - 72 hours after the patient inclusion3
Assessment of patient satisfaction with medical follow-up via a question asked directly to the patient via a questionnaire (Better if more than 50 percent of patients are satisfied)
Time frame
At 1 month after the consultation in the Emergency department4
Assessment of patients' knowledge of antibiotic resistance via a question asked directly to the patient via a questionnaire (Better if more than 50 percent of patients are satisfied)
Time frame
At 1 month after the consultation in the Emergency departmentSponsors and contacts
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Source ClinicalTrials.gov