The objective of this study is to utilize all donated pediatric tumor tissues and cells obtained from autopsy to prospectively develop novel patient derived orthotopic xenograft (PDOX) mouse models as well as in vitro cell culture model systems for pediatric cancers, and also provide tissue samples to other researchers and organizations (eg, CBTN, DIPG Registry, COG).
Pediatric patients with cancer and non-cancer tumor types (solid, liquid, neuro-oncology)
Signed consent for post mortem tissue donation and autopsy
Signed consent for post mortem tissue donation and autopsy not obtained
Pediatric patients with cancer and non-cancer tumor types (solid, liquid, neuro-oncology)
Cohort
Prospective
Collection of post mortem tissue donation
Other interventionCollection of post mortem tissue from pediatric participants with cancer and non-cancer tumor types from whom post mortem tissue donation and autopsy consent is obtained.
Procurement of pediatric cancer and non-cancer tumor tissue during autopsy with signed consent
Procurement of pediatric cancer and non-cancer tumor tissue during autopsy with signed consent. Tissue will be collected through a research tissue collection autopsy of the original tumor and other sites that are appropriate. Samples of both tumor and normal cells will be collected in addition to body fluids such as cerebrospinal fluid (CSF), blood, bone marrow, and skin biopsies for genomic testing.
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