This study aims to determine whether postoperative hypoxia (arterial partial pressure of oxygen (PaO₂)\<80 mmHg) is an independent risk factor for anastomotic leakage after esophagectomy. The investigators conducted a retrospective analysis of cases from their center over the past five years, stratifying patients into Low Pa0₂ Group and Normal Pa0₂ Group based on postoperative oxygen levels and comparing the incidence of anastomotic leakage between the groups. The goal is to establish whether hypoxia is a causative risk factor and whether correcting it can reduce the risk of anastomotic leakage.
Patients diagnosed with esophageal carcinoma or benign esophageal tumors
Patients requiring surgical resection of the lesion with subsequent esophageal reconstruction
Patients must have had at least one postoperative arterial blood gas analysis
Patients must have routinely undergone at least one of the following for postoperative evaluation of the anastomosis: endoscopy, CT scan, or esophagram
Patients who did not require esophageal reconstruction
Patients undergoing esophageal replacement with colon
Patients with incomplete data
This retrospective cohort study included patients diagnosed with esophageal carcinoma or benign esophageal tumors who required surgical resection of the lesion followed by esophageal reconstruction. All patients had at least one postoperative arterial blood gas analysis, and anastomotic healing was assessed via esophagram, CT scan, endoscopy, or typical clinical sign.
Cohort
Retrospective
Not listed
Esophageal Anastomotic Leakage Rate
Anastomotic leak was confirmed by either barium swallow study, CT scan, or endoscopy, or was clinically considered in cases with obvious salivary secretion from the cervical anastomosis. The esophageal anastomotic leakage rate was calculated as (the number of patients with a confirmed anastomotic leakage / the total number of patients who underwent esophagectomy) × 100%.
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Sun Yat-sen University
Lead sponsor
Sichuan Cancer Hospital and Research Institute
Collaborator
Affiliated Hospital of North Sichuan Medical College
Collaborator
Hebei Medical University Fourth Hospital
Collaborator
Affiliated Cancer Hospital of Shantou University Medical College
Collaborator
Shanghai Chest Hospital
Collaborator
